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In Stock Series | Iodo-dG (CAS: 172163-62-1): A Structurally Modified Nucleoside Engineered for High-GC Templates and Functionalization

2025/11/28 11:04:03 Browse volume(6)


Nucleoside Raw Materials

7-Deaza-2'-deoxy-7-iodoguanosine


Continuing from the previous application of Iodo dA in second-generation sequencing, the sequencing challenges of high GC regions and complex secondary structures also exist in dG templates.

7-Deaza-2'-deoxy-7-iodoguanosine (Iodo dG) is a highly functionalized nucleoside that emerged under this background. Through dual modifications of deazation (7-Deaza) and iodination (7-Iodo), it provides a nucleoside raw material that is both stable and functionalizable, offering a new choice for sequencing optimization and multifunctional nucleic acid design.

I. Product Overview

172163-62-1 Structural Formula

Chinese Name: 7-Deaza-7-iodo-2′-deoxyguanosine

English Name: 7-Deaza-2'-deoxy-7-iodoguanosine

Abbreviation: Iodo dG

CAS Number: 172163-62-1

Molecular Formula: C11H13IN4O4

Molecular Weight: 392.15

Specification: 1 g / 25 g / 100 g (custom packaging supported)

Form: Off-white powder

Product Number: G09010002

Stock: Kilogram-scale stock available



II. Working Principle

Iodo dG's dual modification principle: Stable + Controllable + Expandable

1. 7-Deaza (Deaza)

· Replaces the N7 nitrogen atom in the guanine ring with carbon;

· Reduces protonation tendency, enhances chemical stability;

· Improves signal-to-noise ratio and peak shape stability in high GC region sequencing;

2. 7-Iodo (Iodination)

· Introduces an iodine atom at position 7, forming a highly reactive chemical handle;

· Can be used for conjugation with fluorophores, biotin, affinity tags, and functional probes;

· Provides an expandable interface for nucleic acid drugs and functionalized nucleic acids;

Synergistic effects:

1.Enhanced stability → Reduced background noise;

2.Stacking optimization → Polymerase smoothly traverses structures like hairpins and stem-loops;

3.Highly reactive site → Supports multifunctional nucleic acid design;



III. Core Advantages

High-purity structurally modified nucleoside: Suitable for sequencing templates, oligonucleotide synthesis, and functional nucleic acid design;

Strong system compatibility: Supports second-generation sequencing systems and mainstream DNA synthesis platforms;

High stability: Dual modifications improve molecular resistance to degradation, adapting to high temperatures and buffer systems;

Flexible supply: Kilogram-scale stock reserves, supporting custom packaging from milligrams to kilograms;

Domestic quality assurance: Products are verified by HPLC quality control, with stable and reliable performance, suitable for high-standard experiments and industrial needs, and can stably replace imported raw materials;



IV. Application Scenarios

1.Second-generation sequencing system optimization: Used to construct stable high-GC templates, effectively reducing background noise, improving sequencing read length and coverage uniformity;

2.Oligonucleotide chemical synthesis: As a modified monomer, introduces functional sites into oligonucleotides, enabling efficient synthesis and structural control;

3.Nucleic acid functionalization and labeling: The 7-iodo group can serve as a chemical interface for conjugation or substitution, suitable for fluorescent labeling, affinity tags, or probe molecule construction;

4.Nucleic acid drug development: Provides stable and highly reactive linkage points for ApDC or functional nucleic acids, supporting drug design and delivery optimization;




Extended Services

Choose high-purity, stably supplied professional Iodo dG raw materials to accelerate your R&D process.

For high-quality nucleoside raw materials or custom packaging services, please call +86 13302967066!

Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd. focuses on providing reliable domestic alternative solutions for gene sequencing, molecular diagnosis, and microbial detection.


In Vitro Molecular Diagnosis | Gene Sequencing | Microbial Detection


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Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd.

Established in 2015, it is a high-tech enterprise focusing on the R&D, production, and sales of biochemical reagent raw materials in fields such as microbial detection, gene sequencing, and in vitro molecular diagnosis. Committed to providing high-quality biochemical reagent raw materials and professional custom synthesis services, the product range covers more than ten categories and nearly a thousand innovative products. Adhering to the core philosophy of "customer first, integrity and professionalism", we serve wholeheartedly to meet customers' diverse needs in research and testing.

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