Product List
- News Center:
- Home>
- News Center>
- Company News>
- News Details
In Stock Series | Iodo-dG (CAS: 172163-62-1): A Structurally Modified Nucleoside Engineered for High-GC Templates and Functionalization
2025/11/28 11:04:03 Browse volume(129)Nucleoside Raw Materials
7-Deaza-2'-deoxy-7-iodoguanosine
Continuing from the previous application of Iodo dA in second-generation sequencing, the sequencing challenges of high GC regions and complex secondary structures also exist in dG templates.
7-Deaza-2'-deoxy-7-iodoguanosine (Iodo dG) is a highly functionalized nucleoside that emerged under this background. Through dual modifications of deazation (7-Deaza) and iodination (7-Iodo), it provides a nucleoside raw material that is both stable and functionalizable, offering a new choice for sequencing optimization and multifunctional nucleic acid design.
I. Product Overview
Chinese Name: 7-Deaza-7-iodo-2′-deoxyguanosine
English Name: 7-Deaza-2'-deoxy-7-iodoguanosine
Abbreviation: Iodo dG
CAS Number: 172163-62-1
Molecular Formula: C11H13IN4O4
Molecular Weight: 392.15
Specification: 1 g / 25 g / 100 g (custom packaging supported)
Form: Off-white powder
Product Number: G09010002
Stock: Kilogram-scale stock available
II. Working Principle
Iodo dG's dual modification principle: Stable + Controllable + Expandable
1. 7-Deaza (Deaza)
· Replaces the N7 nitrogen atom in the guanine ring with carbon;
· Reduces protonation tendency, enhances chemical stability;
· Improves signal-to-noise ratio and peak shape stability in high GC region sequencing;
2. 7-Iodo (Iodination)
· Introduces an iodine atom at position 7, forming a highly reactive chemical handle;
· Can be used for conjugation with fluorophores, biotin, affinity tags, and functional probes;
· Provides an expandable interface for nucleic acid drugs and functionalized nucleic acids;
Synergistic effects:
1.Enhanced stability → Reduced background noise;
2.Stacking optimization → Polymerase smoothly traverses structures like hairpins and stem-loops;
3.Highly reactive site → Supports multifunctional nucleic acid design;
III. Core Advantages
✅ High-purity structurally modified nucleoside: Suitable for sequencing templates, oligonucleotide synthesis, and functional nucleic acid design;
✅ Strong system compatibility: Supports second-generation sequencing systems and mainstream DNA synthesis platforms;
✅ High stability: Dual modifications improve molecular resistance to degradation, adapting to high temperatures and buffer systems;
✅ Flexible supply: Kilogram-scale stock reserves, supporting custom packaging from milligrams to kilograms;
✅ Domestic quality assurance: Products are verified by HPLC quality control, with stable and reliable performance, suitable for high-standard experiments and industrial needs, and can stably replace imported raw materials;
IV. Application Scenarios
1.Second-generation sequencing system optimization: Used to construct stable high-GC templates, effectively reducing background noise, improving sequencing read length and coverage uniformity;
2.Oligonucleotide chemical synthesis: As a modified monomer, introduces functional sites into oligonucleotides, enabling efficient synthesis and structural control;
3.Nucleic acid functionalization and labeling: The 7-iodo group can serve as a chemical interface for conjugation or substitution, suitable for fluorescent labeling, affinity tags, or probe molecule construction;
4.Nucleic acid drug development: Provides stable and highly reactive linkage points for ApDC or functional nucleic acids, supporting drug design and delivery optimization;
Extended Services
Choose high-purity, stably supplied professional Iodo dG raw materials to accelerate your R&D process.
For high-quality nucleoside raw materials or custom packaging services, please call +86 13302967066!
Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd. focuses on providing reliable domestic alternative solutions for gene sequencing, molecular diagnosis, and microbial detection.
Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd.
Established in 2015, it is a high-tech enterprise focusing on the R&D, production, and sales of biochemical reagent raw materials in fields such as microbial detection, gene sequencing, and in vitro molecular diagnosis. Committed to providing high-quality biochemical reagent raw materials and professional custom synthesis services, the product range covers more than ten categories and nearly a thousand innovative products. Adhering to the core philosophy of "customer first, integrity and professionalism", we serve wholeheartedly to meet customers' diverse needs in research and testing.
Get the latest product updates
GeneSeqTools WeChat Official Account: GeneSeqTools Bioscience
GeneSeqTools Official Website: http://www.geneseqtools.com
Consultation Hotline: +86 0755-23251735
QQ: 2370561481
Email: sales@geneseqtools.com
Related Links
- · FAQs about Geneseqtools BioTech [2024-07-04]
- · Hot Product | 3-Indolyl β-D-glucopyranoside (Y-Glc, CAS: 487-60-5): A Chromogenic Substrate for β-Glucosidase Detection [2025-12-09]
- · In Stock | 5-Ethynyl-dUTP (CAS: 111289-87-3): A High-Efficiency DNA Labeling Reagent for Sequencing and Nucleic Acid Diagnostic Kit Development [2025-12-12]
- · In Stock Series | X-NeuNAc (CAS: 160369-85-7): A Classic Chromogenic Substrate for Sialidase Detection in Bacterial Vaginosis (BV) Diagnostics [2025-12-18]
- · In Stock Series | Alkaline Phosphatase Chromogenic Substrates: Powering Precise Microbial Differentiation in Food Safety Testing [2025-12-25]
- · GeneSeqTools Leads the Way Like a Golden Steed—Together We Forge Ahead on a Journey of Ten Thousand Miles in 2026 [2025-12-29]
- · In Stock Series | Chromogenic Substrates for α-D-Galactosidase: Precisely Target Enterococcus and Other Indicator Microbes [2026-01-07]
- · In Stock Series | Simplifying β-D-Galactosidase Detection: A One-Stop Solution from Chromogenic to Fluorescent Substrates [2026-01-14]
- · 【Domestic Exclusive – In Stock】Refined Through Three Generations of Innovation: Acridinium Ester Label NSP-DMAE-HEG-Glu-NHS [2026-01-20]

