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In Stock Series | Iodo-dG (CAS: 172163-62-1): A Structurally Modified Nucleoside Engineered for High-GC Templates and Functionalization
2025/11/28 11:04:03 Browse volume(6)Nucleoside Raw Materials
7-Deaza-2'-deoxy-7-iodoguanosine
Continuing from the previous application of Iodo dA in second-generation sequencing, the sequencing challenges of high GC regions and complex secondary structures also exist in dG templates.
7-Deaza-2'-deoxy-7-iodoguanosine (Iodo dG) is a highly functionalized nucleoside that emerged under this background. Through dual modifications of deazation (7-Deaza) and iodination (7-Iodo), it provides a nucleoside raw material that is both stable and functionalizable, offering a new choice for sequencing optimization and multifunctional nucleic acid design.
I. Product Overview
Chinese Name: 7-Deaza-7-iodo-2′-deoxyguanosine
English Name: 7-Deaza-2'-deoxy-7-iodoguanosine
Abbreviation: Iodo dG
CAS Number: 172163-62-1
Molecular Formula: C11H13IN4O4
Molecular Weight: 392.15
Specification: 1 g / 25 g / 100 g (custom packaging supported)
Form: Off-white powder
Product Number: G09010002
Stock: Kilogram-scale stock available
II. Working Principle
Iodo dG's dual modification principle: Stable + Controllable + Expandable
1. 7-Deaza (Deaza)
· Replaces the N7 nitrogen atom in the guanine ring with carbon;
· Reduces protonation tendency, enhances chemical stability;
· Improves signal-to-noise ratio and peak shape stability in high GC region sequencing;
2. 7-Iodo (Iodination)
· Introduces an iodine atom at position 7, forming a highly reactive chemical handle;
· Can be used for conjugation with fluorophores, biotin, affinity tags, and functional probes;
· Provides an expandable interface for nucleic acid drugs and functionalized nucleic acids;
Synergistic effects:
1.Enhanced stability → Reduced background noise;
2.Stacking optimization → Polymerase smoothly traverses structures like hairpins and stem-loops;
3.Highly reactive site → Supports multifunctional nucleic acid design;
III. Core Advantages
✅ High-purity structurally modified nucleoside: Suitable for sequencing templates, oligonucleotide synthesis, and functional nucleic acid design;
✅ Strong system compatibility: Supports second-generation sequencing systems and mainstream DNA synthesis platforms;
✅ High stability: Dual modifications improve molecular resistance to degradation, adapting to high temperatures and buffer systems;
✅ Flexible supply: Kilogram-scale stock reserves, supporting custom packaging from milligrams to kilograms;
✅ Domestic quality assurance: Products are verified by HPLC quality control, with stable and reliable performance, suitable for high-standard experiments and industrial needs, and can stably replace imported raw materials;
IV. Application Scenarios
1.Second-generation sequencing system optimization: Used to construct stable high-GC templates, effectively reducing background noise, improving sequencing read length and coverage uniformity;
2.Oligonucleotide chemical synthesis: As a modified monomer, introduces functional sites into oligonucleotides, enabling efficient synthesis and structural control;
3.Nucleic acid functionalization and labeling: The 7-iodo group can serve as a chemical interface for conjugation or substitution, suitable for fluorescent labeling, affinity tags, or probe molecule construction;
4.Nucleic acid drug development: Provides stable and highly reactive linkage points for ApDC or functional nucleic acids, supporting drug design and delivery optimization;
Extended Services
Choose high-purity, stably supplied professional Iodo dG raw materials to accelerate your R&D process.
For high-quality nucleoside raw materials or custom packaging services, please call +86 13302967066!
Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd. focuses on providing reliable domestic alternative solutions for gene sequencing, molecular diagnosis, and microbial detection.
Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd.
Established in 2015, it is a high-tech enterprise focusing on the R&D, production, and sales of biochemical reagent raw materials in fields such as microbial detection, gene sequencing, and in vitro molecular diagnosis. Committed to providing high-quality biochemical reagent raw materials and professional custom synthesis services, the product range covers more than ten categories and nearly a thousand innovative products. Adhering to the core philosophy of "customer first, integrity and professionalism", we serve wholeheartedly to meet customers' diverse needs in research and testing.
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